Ovagen
The Overall Wellness Enhancer
Enhance Overall Well-being: Comprehensive Liver Health Benefits of Ovagen
Ovagen is a complex of peptides derived from the liver of animals. These peptides are thought to have a regulatory effect on the liver and gastrointestinal tract in humans. The primary proposed function of Ovagen is to restore, normalize, and enhance the functions of the liver and intestines by influencing the cells directly. It is used to support the liver in cases of damage, to enhance detoxification processes, and to generally support digestive health. Ovagen are believed to work by entering the bloodstream, reaching the targeted organs, and interacting with the cells to stimulate repair and regeneration processes. This might include promoting the synthesis of proteins necessary for cell repair, regulating the immune response, or enhancing metabolic processes.
Potential Benefits Under Research
- Liver Regeneration and Protection: Ovagen is studied for its potential to help regenerate liver cells and protect the liver from damage caused by toxins, alcohol, and other harmful substances.
- Enhancement of Detoxification Processes: The peptides in Ovagen may enhance the liver’s ability to detoxify the body, potentially aiding in the removal of harmful substances more efficiently.
- Improvement in Digestive Health: By promoting healthier liver and gastrointestinal function, Ovagen might help improve overall digestive health, potentially reducing issues like bloating, constipation, and diarrhea.
- Support in Metabolic Processes: Ovagen might play a role in optimizing metabolic functions, which can contribute to better energy utilization and overall health.
- Immune System Modulation: There’s interest in how Ovagen may help modulate the immune system, potentially reducing inflammation and supporting the body’s natural defense mechanisms.
- Potential Anti-Aging Effects: By promoting cell regeneration and optimizing organ function, Ovagen might contribute to an overall anti-aging effect, although this is a more speculative area of research.
Overview
Ovagen is a tripeptide bioregulator that should not be confused with the similarly named Ovagen that contains ovine (sheep) follicle stimulating hormone (FSH). The two products are not the same and have entirely different functions. While the FSH derivative promotes ovulation, particularly in women suffering from conditions like polycystic ovarian syndrome
(PCOS), the tripeptide is a liver function regulator. Throughout this article, Ovagen will refer to the tripeptide bioregulator.
Ovagen is a Khavinson peptide, developed along with a number of other peptides, by Dr. Vladimir Khavinson. Like other bioregulators, Ovagen is able to cross cell and nuclear membranes to directly regulate DNA structure and transcription patterns. Also, like most other bioregulatory peptides, Ovagen has tissue-specific effects. The Glu-Asp-Leu peptide primarily serves to regulate and normalize liver and digestive tract function, though there is some evidence to suggest it may also be useful in controlling the reproduction of the HIV virus. This latter finding has made Ovagen of interest to HIV researchers looking to understand the virus lifecycle.
Structure
Amino Acid Sequence: Glu-Asp-Leu (EDL) Molecular Formula: C1sH2sN3Oa
Molecular Weight: 375.37 g/mol
PubChem CID: 444128
Synonyms: EDL, glutamyl-aspartyl-leucine, SCHEMBL5329396, la30, CHEBl:137252
Source: PubChem
Ovagen and the Liver
According to research from Dr. Khavinson, Ovagen is a bioregulator of the GI tract and liver. In the liver, it has been found to promote cell proliferation and prevent scarring and fibrotic changes that can lead to cirrhosis. In the GI tract, Ovagen helps to boost mucosal barrier function and reduces complications from antibiotic treatment, environmental insults, chemotherapy, malnutrition, and more.
Like most bioregulators, the most robust effects of Ovagen are seen in older individuals. The peptide appears to roll back DNA changes that occur with age, helping to reset the DNA in liver fibroblasts and GI mucosal cells to a more youthful state. In this more youthful state, the DNA is less condensed and therefore more genes are available for transcription. This results in a more functional cell that is less senescent and therefore “healthier.”
Research shows that Ovagen is well tolerate and may be useful in normalizing the function of the liver and GI tract in a number of different inflammatory and disease conditions. It may also be useful in the postoperative setting, during long-term antibiotic therapy, for overcoming the side effects of cancer treatments, and even as a diabetes preventative. Research on the GI and liver effects of Ovagen is ongoing.
Ovagen and HIV
The HIV-1 protease is an enzyme necessary for the HIV virus to survive. It functions to cleave newly synthesized proteins that make up the mature HIV virion. This infectious form of the HIV virus will not function without the HIV-1 protease. In other words, the enzyme is essential for the HIV virus to be able to infect more cells. Without the protease, the HIV virus produces non-infectious progeny and dies out. A number of HIV protease inhibitors are currently FDA approved and used in treatment. Unfortunately, the virus’s high mutation rate results in relatively rapid formation of resistance.
Research on Ovagen reveals that it is an effective HIV-1 protease inhibitor. In fact, it is one of the smallest and most potent protease inhibitors known with an effective concentration of just 50 microns. Unlike other protease inhibitors, Ovagen is highly soluble in water. This latter fact makes it easier to administer.
Ovagen Summary
Ovagen is a tripeptide bioregulator with primary effects in the liver and GI tract. Though research on this Khavinson peptide is limited at this point, it has shown promise as a potential anti-aging peptide in the liver and GI tract. Ovagen reduces long-term fibrosis in the liver and helps to protect the GI mucosal layer from the effects of antibiotics, environmental toxins, and even chemotherapy. There is also interest in the ability of Ovagen to inhibit the replication of HIV.
Article Author
The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.
Scientific Journal Author
Vladimir Khavinson is a Professor, resident of the European region of the International Association of Gerontology and Geriatrics; Member of the Russian and Ukrainian Academies of Medical Sciences; Main gerontologist of the Health Committee of the Government of Saint Petersburg, Russia; Director of the Saint Petersburg Institute of Bioregulation and Gerontology; Vice president of Gerontological Society of the Russian Academy of Sciences; Head of the Chair of Gerontology and Geriatrics of the North-Western State Medical University, St-Petersburg; Colonel of medical service (USSR, Russia), retired. Vladimir Khavinson is known for the discovery, experimental and clinical studies of new classes of peptide bioregulators as well as for the development of bioregulating peptide therapy. He is engaged in studying of the role of peptides in regulation of the mechanisms of ageing. His main field of actions is design, pre-clinical and clinical studies of new peptide geroprotectors. A 40-yearlong investigation resulted in a multitude of methods of application of peptide bioregulators to slow down the process of aging and increase human life span. Six peptide-based pharmaceuticals and 64 peptide food supplements have been introduced into clinical practice by V. Khavinson. He is an author of 196 patents (Russian and international) as well as of 775 scientific publications. His major achievements are presented in two books: “Peptides and Ageing” (NEL, 2002) and “Gerontological aspects of genome peptide regulation” (Karger AG, 2005). Vladimir Khavinson introduced scientific specialty
“Gerontology and Geriatrics” in the Russian Federation on the governmental level. Academic Council headed by V. Khavinson has oversighted over 200 Ph.D. and Doctorate theses from many different countries.
Prof. Vladimir Khavinson is being referenced as one of the leading scientists involved in the research and development of Ovagen. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between Guide to Peptide and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide.