Vesilute

The Bladder Health Protector

Protect Bladder Health: Discover the Benefits of Vesilute

Vesilute peptide bioregulators are a specific type of biologically active compounds designed to support and regulate the functions of the bladder. Vesilute peptides interact directly with the DNA in bladder cells, potentially influencing the expression of genes that regulate cellular repair and function. This interaction aims to optimize the functioning of bladder cells and maintain their health. Vesilute is primarily used to potentially enhance bladder function and is considered in therapeutic strategies for age-related decline in organ function or specific bladder conditions.

Potential Benefits Under Research

• Enhanced Bladder Function: May improve overall bladder function, aiding in the management of urinary frequency and urgency.
• Cellular Repair and Regeneration: Potential to promote the repair and regeneration of bladder tissue, which could be beneficial in cases of damage or aging.
• Regulation of Cellular Processes: By influencing gene expression in bladder cells, these peptides might help in maintaining cellular health and preventing dysfunction.
• Anti-aging Effects: Could contribute to slowing down age-related decline in bladder function, supporting healthier aging.
• Improved Tissue Resilience: May enhance the resilience of bladder tissues against environmental or physiological stresses.

Overview

Dipeptides are either organ-specific or are widely present throughout a variety of tissues. Vesilute is one of the latter dipeptides, being found throughout the body. Vesilute is one of the least studied Khavinson peptides, but has shown some effect on bladder and genitourinary system tissues. Research reports indicate that Vesilute can improve bladder function, particularly in the elderly, assisting with chronic cystitis, benign prostatic hyperplasia (BPH) and a variety of urinary problems. The peptide has important organotrophic effects in the prostate as well, helping to prevent cell proliferation and prostate enlargement. Research suggests that this effect may be the result of improvements in microcirculation. 

Vesilute and other cytomedines appear to have beneficial effects on sperm quality and fertility. Research out of Russia indicates an increase in sperm production, health, and viability with administration of cytomedines. There is, additionally, a decrease in the number of abnormal sperm. All of these effects serve to increase fertility. 

Interestingly, the Glu-Asp peptide, along with twelve other dipeptides, has been shown to be responsible for umami flavor in a variety of settings. Though not directly related to health and wellness, the fact that these peptides produce a desirable flavor suggests that their ingestion may be encouraged via evolutionary taste mechanisms. This could, though by no means has been proven to, indicate that these peptides have an important role in basic biochemical processes. Vesilute and other cytomedines have been shown to be orally active. 

Structure

Amino Acid Sequence: Glu-Asp (ED)
Molecular Formula: C9H14N201
Molecular Weight: 262.20 g/mol
PubChem CID: 99716
CAS Number: 3918-84-1
Synonyms: alpha-glutamylaspartic acid, SCHEMBL1674753, vesilut, ED dipeptide

Source: PubChem 

Vesilute and Smooth Muscle Function 

Vesilute is thought to have anti-aggregation effects on the muscles of the bladder wall. In muscle, glycogen serves as an important form of energy storage. This multibranched polysaccharide is a short-term energy storage solution and is found primarily in muscle and liver cells. It makes up approximately 2% of muscle mass where it serves as an immediate source of glucose to maintain contraction. 

Glycogen is broken down by an enzyme called glycogen phosphorylase. At rest, glycogen phosphorylase B is in a tense state due to the presence of ATP and certain enzymes. In its tense form, phosphorylation B is unable to bind with glycogen and therefore cannot break it down. Without the ability to break down glycogen into glucose, muscle is unable to maintain contraction and is forced to relax. 

There are multiple stimuli for aggregation in skeletal muscle including the generation of thermal energy (heat), increases in AMP levels, and increases in calcium ion levels. Vesilute appears to interfere with the process of aggregation at a universal step, thereby preventing glycogen breakdown by any mechanism. This, in turn, induces smooth muscle relaxation. Relaxation of smooth muscle ends the signals calling for more energy and can help to break the cycle that leads to spasms. Because smooth muscle is dependent on calcium signals for maintenance, breaking the spasmodic cycle by reducing calcium levels and dissipating heat can lead to long-term relief from spasms. These effects would be highly prominent in the urinary tract where smooth muscle is abundant. 

Vesilute and Blood Vessels 

The effects of Vesilute, which is considered to be a cytomedine peptide, would also be prominent in the vasculature where smooth muscle reigns supreme. Cytomedines, according to Vladimir Khavinson, are peptide bioregulators that prevent premature aging. In this case, interruption of aggregation would lead to vessel relaxation. This would lead to lower blood pressure, reduced energy expenditure in the heart, and improved nutrient delivery to organs throughout the body. Thus, Vesilute 20mg likely has beneficial effects on blood pressure, the long-term health of the vascular system, and several end organs like the heart, brain, and kidneys.

It is thought that the benefits of Vesilute on the prostate are due to its microvascular effects. Improved circulation in the prostate helps to reduce inflammation, improve blood flow, and rid the prostate of toxins. The net effect of improved microvascular circulation in the prostate is a decrease in fibrosis and enlargement of the prostate gland. Research shows that prostate massage has a similar effect. 

Vesilute and Fertility 

Interestingly, decreasing prostatitis by increasing microvascular supply to the gland via cytomedines like Vesilute appears to have an impact on spermatogenesis. Sperm levels following treatment of prostatitis increase as much as 29% and show more than a 14% increase in viability. Research shows that men treated with cytomedines like Vesilute experience an increase in fertility without intolerable side effects. 

Vesilute Summary 

Vesilute is a Khavinson peptide with research exploring its role in regulating the urinary tract and prostate gland. Research evidence indicates that Vesilute may help to relieve symptoms associated with bladder and urinary tract dysfunction. Vesilute and other cytomedines have been shown to reduce prostate dysfunction and are thought to act by improving microcirculation in the prostate and by reducing cell proliferation. The latter effect may be due to changes in chromosome density and epigenetic factors, a mechanism of cellular regulation that is common among Khavinson peptides. 

Article Author

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology. 

Scientific Journal Author 

Vladimir Khavinson is a Professor, resident of the European region of the International Association of Gerontology and Geriatrics; Member of the Russian and Ukrainian Academies of Medical Sciences; Main gerontologist of the Health Committee of the Government of Saint Petersburg, Russia; Director of the Saint Petersburg Institute of Bioregulation and Gerontology; Vice ­president of Gerontological Society of the Russian Academy of Sciences; Head of the Chair of Gerontology and Geriatrics of the North-Western State Medical University, St-Petersburg; Colonel of medical service (USSR, Russia), retired. Vladimir Khavinson is known for the discovery, experimental and clinical studies of new classes of peptide bioregulators as well as for the development of bioregulating peptide therapy. He is engaged in studying of the role of peptides in regulation of the mechanisms of ageing. His main field of actions is design, pre-clinical and clinical studies of new peptide geroprotectors. A 40-year­long investigation resulted in a multitude of methods of application of peptide bioregulators to slow down the process of aging and increase human life span. Six peptide-based pharmaceuticals and 64 peptide food supplements have been introduced into clinical practice by V. Khavinson. He is an author of 196 patents (Russian and international) as well as of 775 scientific publications. His major achievements are presented in two books: “Peptides and Ageing” (NEL, 2002) and “Gerontological aspects of genome peptide regulation” (Karger AG, 2005). Vladimir Khavinson introduced scientific specialty “Gerontology and Geriatrics” in the Russian Federation on the governmental level. Academic Council headed by V. Khavinson has oversighted over 200 Ph.D. and Doctorate theses from many different countries. 

Prof. Vladimir Khavinson is being referenced as one of the leading scientists involved in the research and development of Vesilute. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between Guide to Peptide and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide. 

Referenced Citations 

1. E. Heidenreich et al., “A Novel UPLC-MS/MS Method Identifies Organ-Specific Dipeptide Profiles/’ Int. J. Mo/. Sci., vol. 22, no. 18, 11:. 9979, Sep. 2021, doi: 10.3390/ijms22189979.
2. A. A. Kamalov, E. A. Efremov, S. D. Dorofeev, and S. M. Paniushkin, “[Use of oral vitaprost in the treatment of chronic abacterial prostatitis],” Urol. Mose. Russ. 1999, no. 5, pp. 45-50, Oct. 2006. 
3. Y. Kong et al., “Comparison of non-volatile umami components in chicken soup and chicken enzymatic hydrolysate,” Food Res. Int., vol. 102, pp. 559-566, Dec. 2017, doi: 10.1016/j.foodres.2017 .09.038. 
4. T. B. Eronina et al., “Effect of Groel on thermal aggregation of glycogen phosphorylase b from rabbit skeletal muscle,” Macromol. Biosci., vol. 10, no. 7, pp. 768- 774, Jul. 2010, doi: 10.1002/mabi.200900396. 
5. “GIycogen Phosphorlase B – an overview I ScienceDirect Topics.”
   https://www.sciencedirect.com/topics/neurosci ence/glycogen-phosphotylase-b ( accessed Feb. 26, 2022).
6. V. G. Morozov and V. K. Khavinson, :[Prospects of Cytomedines application in clinical medicine and gerontologyl.” Klin. Med.  .(Mosk.), vol. 78, no. 2, RR- 42-45, 2000. 
7. B. A Neymark, A I. Neymark, AV. Dayydov, I. I. KleRikova, N. A Nozdrachev, and M. V. Razdorskaya, “[ROLE OF CYTOMEDINES IN THE TREATMENT OF PATIENTS WITH CHRONIC PROSTATITIS ASSOCIATED WITH IMPAIRED SPERMATOGENESIS]i: Urol. Mose. Russ. 1999, no. 5, RR· 70, 72-73, Oct. 2015