Fundamental difference
SARMs are small molecules (similar to steroids structurally) that selectively bind androgen receptors. Peptides are amino acid chains (8-50 typically) acting on diverse receptor families.
Comparison
| SARMs | Peptides | |
|---|---|---|
| Class | Small molecule androgen receptor modulators | Amino acid chain signaling molecules |
| Route | Oral typically | Subcutaneous typically |
| Liver toxicity | Mild to moderate | Generally none |
| HPTA suppression | Yes (less than steroids) | Class-dependent |
| FDA status | None approved for general use | Some approved (GLP-1s, etc.) |
Common SARMs vs Peptides
Popular SARMs: Ostarine (MK-2866), Ligandrol (LGD-4033), RAD-140 (Testolone), Cardarine (GW-501516 — technically PPAR agonist, not SARM).
Which is better for muscle gain?
SARMs typically faster acute effects; peptides more sustainable long-term.